Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma
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منابع مشابه
Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma
Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers. In the present study, we found that Aurora B is overexpressed in human esophageal squamous cell carcinoma (ESCC), high levels of Aurora B protein were associated with a worse overall survival rate in ESCC patients. Depleting of A...
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Article history: Received 15 November 2017 Accepted 15 November 2017 Available online 16 November 2017 example targeting Raf-1, Bcr, and Cdc25 phosphatase. Deguelin has the potential to impair 14-3-3 protein function through inhibition of Aurora B function.Deguelin can induce partial synchronization of cancer cells in the most radio-or DNA damaging agents-sensitive to G2-M phase, although it ne...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2017
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2017.10.030